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Different areas other hand, supplementary estradiol (a common natural estrogen) is known to greatly disrupts metabolic rate and protein production) Cardiomyopathy (disease of the cardiac muscle, increasing the risk of arrhythmia and sudden cardiac death) Hypercholesterolaemia (presence of high levels of cholesterol in the blood) Ischaemic heart disease (a lack of blood to the heart, often due to coronary artery disease) Myopathies (neuromuscular diseases affecting the function of muscle fibres) Menstrual irregularities.